International PhD Program in Neuropharmacology XXV Cycle THE GLUTAMATE HYPOTHESIS OF DEPRESSION: THE EFFECT OF STRESS AND GLUCOCORTICOIDS ON GLUTAMATE SYNAPSE AND THE ACTION OF ANTIDEPRESSANTS Doctorate thesis
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چکیده
.............................................................................. 5 Introduction ..................................................................................... 11 1 Depression ............................................................................... 13 2 The stress response ................................................................ 16 2.1 The HPA axis ........................................................................... 16 2.2 Corticosteroid receptors .......................................................... 19 2.2.1 Classical cytosolic corticosteroid receptors .............................. 21 2.2.2 Novel membrane-associated corticosteroid receptors ............. 22 2.3 Rapid corticosteroid effects in the brain ................................... 23 2.4 Delayed effects of corticosteroids ............................................ 25 2.5 Chronic corticosteroid exposure............................................... 26 3 Stress as a risk factor for neuropsychiatric disorders ............... 29 4 New approaches in neuropsychopharmacology: the glutamatergic hypothesis of depression ................................... 32
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